The research literature sets three limits before results are used.
The first is sample size. According to the ESOMAR guide, providers recommend samples of 15 to 30 people, against 100 or more in traditional research. Ariely and Berns note that any task in which the response is expected to vary across individuals needs a sample of at least 30. Button and colleagues (2013) estimated the median statistical power of neuroscience studies at between 8 % and 31 %: with low power, real effects are harder to detect and a statistically significant result is less likely to reflect a true effect.
The second is reverse inference. A brain region lighting up does not prove a particular feeling, because a region takes part in several processes. Russell Poldrack showed in 2006 that such inferences are not deductively valid, although they can provide some information. Ariely and Berns warn against anyone who claims to know what a person thinks from brain activation alone.
The third is that a reaction is not a purchase. Some studies link the two. Knutson and colleagues (2007) scanned 26 adults with fMRI, and activity in each of three regions predicted their immediate purchase decisions in the lab beyond what they reported themselves. Venkatraman and colleagues (2015) compared six methods with real sales after TV ads, and fMRI explained the most variance beyond the traditional measures. These are results of individual studies; they do not allow the conclusion that an ad will sell more because it activated a brain region.
Neuromarketing can complement A/B testing and surveys in stages that leave no trace in clicks, such as interest and desire in the AIDA model. It cannot replace them.